[Events] MACSI Seminar (today at 4pm)

[Sarah.Mitchell]

The department of Mathematics and Statistics invites you to a seminar by
Prof. Cathal Seoighe (School of Mathematics, Statistics and Applied
Mathematics, NUIG): 

 

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Title:  A Phylogenetic Hidden Markov Model for Immune Epitope Discovery

Abstract:  We describe a phylogenetic model of protein-coding sequence
evolution that includes environmental variables. We apply it to a set of
viral sequences from individuals with known human leukocyte antigen
(HLA) genotype and include parameters to model selective pressures
affecting mutations within immunogenic (epitope) regions that facilitate
viral evasion of immune responses. We combine this evolutionary model
with a hidden Markov model to identify regions of the HIV-1 genome that
evolve under immune pressure in the presence of specific HLA class I
alleles and may therefore represent potential T cell epitopes. This
phylogenetic hidden Markov model provides a probabilistic framework that
can be combined with sequence or structural information to enhance
epitope prediction. 

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The seminar will take place on Wednesday 21st April, at 4pm, in A2-002.

 

If you have any questions regarding this seminar, please direct them to
Sarah Mitchell (061 202259, sarah.mitchell at ul.ie).  A full list of
Seminars for this semester can be found at: 

 

http://www.staff.ul.ie/mitchells/MACSI_seminars.html
<http://www.staff.ul.ie/mitchells/MACSI_seminars.html> 

 

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Supported by Science Foundation Ireland Mathematics Initiative funding,
MACSI - the Mathematics Applications Consortium for Science and Industry
(www.macsi.ul.ie), centred at the University of Limerick, is dedicated
to the mathematical modelling and solution of problems which arise in
science, engineering and industry in Ireland

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