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<p class=MsoTitle style='margin-bottom:6.0pt'><b><font size=3 color=navy
face=Times><span style='font-size:12.0pt;font-family:Times;color:navy;
text-transform:uppercase'>Materials &</span></font></b><font size=3
color=navy face=Times><span style='font-size:12.0pt;font-family:Times;
color:navy;text-transform:uppercase;font-weight:normal'> </span></font><font
size=3 color=navy face=Times><span style='font-size:12.0pt;font-family:Times;
color:navy;text-transform:uppercase'>Surface Science Institute<o:p></o:p></span></font></p>
<p class=MsoTitle><b><font size=3 color=navy face="Times New Roman"><span
style='font-size:12.0pt;color:navy;text-transform:uppercase'>Research Forum
2010<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=navy face="Times New Roman"><span style='font-size:12.0pt;color:navy;
font-weight:bold'><o:p> </o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=navy face="Times New Roman"><span style='font-size:12.0pt;color:navy;
font-weight:bold'><o:p> </o:p></span></font></b></p>
<h5><b><u><font size=3 color=maroon face="Times New Roman"><span
style='font-size:12.0pt;font-family:"Times New Roman"'>PRESENTATION BY<o:p></o:p></span></font></u></b></h5>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>Dr. <st1:PersonName
w:st="on">Guy Steffens</st1:PersonName><o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><st1:PlaceName w:st="on"><b><font
size=3 face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>RWTH</span></font></b></st1:PlaceName><b><span
style='font-weight:bold'> <st1:PlaceName w:st="on">Aachen</st1:PlaceName> <st1:PlaceType
w:st="on">University</st1:PlaceType>, <st1:place w:st="on"><st1:City w:st="on">Aachen</st1:City>,
<st1:country-region w:st="on">Germany</st1:country-region></st1:place><o:p></o:p></span></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'><o:p> </o:p></span></font></b></p>
<p class=MsoHeading9 style='margin-bottom:6.0pt'><b><u><font size=3
color=maroon face="Times New Roman"><span style='font-size:12.0pt'>TITLE OF
PRESENTATION<o:p></o:p></span></font></u></b></p>
<p class=MsoNormal><u><font size=1 face="Times New Roman"><span
style='font-size:3.0pt'><o:p><span style='text-decoration:none'> </span></o:p></span></font></u></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>(Re)Vascularization
in Tissue Substitutes and Tissue Repair<o:p></o:p></span></font></b></p>
<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
style='font-size:12.0pt;color:black;font-weight:bold'><o:p> </o:p></span></font></b></p>
<h2 style='margin-bottom:6.0pt'><b><font size=3 face="Times New Roman"><span
style='font-size:12.0pt;font-family:"Times New Roman"'>ABSTRACT<o:p></o:p></span></font></b></h2>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'>Vascularization plays a
pivotal role in survival of tissues. Injuries often lead to the cut off of the
oxygen and nutrient supply. These injuries include acute and chronic skin
wounds, as well as burn wounds and the myocardial infarction. Revascularization
will then be required. In the case of large area third degree burn wounds both
the epidermis and the dermis have been destroyed. In order to regain normal
functional skin, (re)vascularization is required. The standard practice in the
treatment of large area burn wounds is covering these wounds with collagen
matrices, such as Integra<sup>®</sup>. At the moment vascularisation in these
matrices is relatively slow. For this reason many researchers have tried to
enhance the angiogenesis by applying angiogenic growth factors such as FGF-2
and VEGF. We also tried to enhance angiogenesis by physically immobilizing VEGF
via covalent incorporation of heparin. During the latter we observed an
additional cross-linking of the collagen fibres, which to our surprise had a rather
big impact on the rate of vascularisation in the collagen matrices. In the last
decade an important role has been attributed to the endothelial progenitor
cells (EPCs), which are claimed to be involved in the (re)vascularisation
process by promoting both angiogenesis and vasculogenesis. We then got involved
in studying the role of CXCR4 and its ligands CXCL12 and MIF (macrophage
migration inhibiting factor) in the recruitment of EPCs to hypoxic and injured
tissues. We recently observed that MIF might play an hitherto unrecognized role
in revascularization and wound healing.</span></font></p>
<p class=textonormal style='margin:0cm;margin-bottom:.0001pt;text-align:justify'><font
size=3 color=black face="Times New Roman"><span style='font-size:12.0pt;
font-family:"Times New Roman"'><o:p> </o:p></span></font></p>
<h2 style='margin-bottom:6.0pt'><b><font size=3 face=Times><span
style='font-size:12.0pt'>ABOUT THE PRESENTER</span></font></b><font
face="Times New Roman"><span style='font-family:"Times New Roman"'><o:p></o:p></span></font></h2>
<p class=MsoNormal style='text-align:justify'><st1:PersonName w:st="on"><font
size=3 face="Times New Roman"><span style='font-size:12.0pt'>Guy Steffens</span></font></st1:PersonName>
received his M.Sc. in 1971 and his Ph.D. in 1975 from <st1:place w:st="on"><st1:PlaceName
w:st="on">RWTH</st1:PlaceName> <st1:PlaceName w:st="on">Aachen</st1:PlaceName>
<st1:PlaceType w:st="on">University</st1:PlaceType></st1:place>. In 1979 and
1980 he was a research associate at the <st1:PlaceType w:st="on">Institute</st1:PlaceType>
of <st1:PlaceName w:st="on">Molecular Biology</st1:PlaceName> of the <st1:PlaceType
w:st="on">University</st1:PlaceType> of <st1:PlaceName w:st="on">Oregon</st1:PlaceName>,
<st1:place w:st="on"><st1:City w:st="on">Eugene</st1:City>, <st1:country-region
w:st="on">USA</st1:country-region></st1:place>. Initially he worked on
structure function relationships in hemoglobin. Later on he switched to the
proteinchemical and functional characterization of mitochondrial and bacterial
cytochrome oxidases. Momentarily his research area concentrates on the
(re)vascularisation of tissue substitutes and in tissue repair, angiogenesis in
collagen matrices, effects of hypoxia on expression and secretion of
chemoattractants and their effects on chemotaxis of cells relevant in wound
healing.</p>
<p class=MsoNormal style='text-align:justify'><font size=2
face="Times New Roman"><span style='font-size:11.0pt'> <o:p></o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=2
face="Times New Roman"><span lang=EN-US style='font-size:11.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><b><font size=3 color=maroon
face="Times New Roman"><span lang=EN-IE style='font-size:12.0pt;color:maroon;
font-weight:bold'>DATE: </span></font></b><font color=maroon><span
lang=EN-IE style='color:maroon'>Thursday, 13 May 2010<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><b><font size=3 color=maroon
face="Times New Roman"><span lang=EN-IE style='font-size:12.0pt;color:maroon;
font-weight:bold'>TIME:</span></font></b><font color=maroon><span lang=EN-IE
style='color:maroon'> 12h00<o:p></o:p></span></font></p>
<p class=MsoNormal><b><font size=3 color=maroon face="Times New Roman"><span
lang=EN-IE style='font-size:12.0pt;color:maroon;font-weight:bold'>VENUE:</span></font></b><font
color=maroon><span lang=EN-IE style='color:maroon'> MSB-012 <st1:place
w:st="on"><st1:PlaceName w:st="on">MSSI</st1:PlaceName> <st1:PlaceType w:st="on">Building</st1:PlaceType></st1:place><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 color=maroon face="Times New Roman"><span
lang=EN-IE style='font-size:12.0pt;color:maroon'><o:p> </o:p></span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=2
color=black face="Times New Roman"><span lang=EN-IE style='font-size:11.0pt;
color:black;font-weight:bold'><o:p> </o:p></span></font></b></p>
<h1 style='margin-bottom:6.0pt'><b><font size=2 face="Times New Roman"><span
style='font-size:11.0pt;font-family:"Times New Roman"'>REFRESHMENTS WILL BE
PROVIDED AT 11h45<o:p></o:p></span></font></b></h1>
<p class=MsoHeading8 style='margin-bottom:6.0pt'><b><font size=2 color=navy
face="Times New Roman"><span style='font-size:11.0pt;color:navy;font-weight:
bold'>For further information, please contact:<o:p></o:p></span></font></b></p>
<p class=MsoHeading8><b><font size=2 face="Times New Roman"><span lang=ES
style='font-size:11.0pt;font-weight:bold'>Dr Teresa Curtin, Tel. </span></font></b><b><font
size=2><span style='font-size:11.0pt;font-weight:bold'>No: (061) 202981 or
Email: <a href="mailto:teresa.curtin@ul.ie">teresa.curtin@ul.ie</a> <o:p></o:p></span></font></b></p>
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